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dba 2 mice  (Jackson Laboratory)

 
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    Jackson Laboratory dba 2 mice
    VVD-065 exhibits strong antitumor effects in syngeneic settings. A and B, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic orthotopic model. KLN-205 cells were injected into the tail vein <t>of</t> <t>DBA/2</t> animals and then dosed with vehicle or VVD-065 50 mg/kg once a day (QD). A, Representative hematoxylin and eosin images of lungs from non-tumor bearing animals, vehicle-treated animals, and VVD-065–treated animals. B, Kaplan–Meier survival analysis comparing VVD-065 with vehicle ( n = 30 animals/group). Statistical significance was calculated by the Gehan–Breslow–Wilcoxon test (****, P < 0.0001). C, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic heterotopic model. Data are shown as mean ± SEM; n = 10 animals/group. Mice were dosed orally with VVD-065 at indicated doses. Statistical significance was calculated by two-way ANOVA (****, P ≤ 0.0001). OS, overall survival.
    Dba 2 Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/dba+2+mice/pmc13133613-428-28-30?v=Jackson+Laboratory
    Average 86 stars, based on 1 article reviews
    dba 2 mice - by Bioz Stars, 2026-06
    86/100 stars

    Images

    1) Product Images from "A Covalent Allosteric Molecular Glue Suppresses NRF2-Dependent Cancer Growth"

    Article Title: A Covalent Allosteric Molecular Glue Suppresses NRF2-Dependent Cancer Growth

    Journal: Cancer Discovery

    doi: 10.1158/2159-8290.CD-25-1187

    VVD-065 exhibits strong antitumor effects in syngeneic settings. A and B, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic orthotopic model. KLN-205 cells were injected into the tail vein of DBA/2 animals and then dosed with vehicle or VVD-065 50 mg/kg once a day (QD). A, Representative hematoxylin and eosin images of lungs from non-tumor bearing animals, vehicle-treated animals, and VVD-065–treated animals. B, Kaplan–Meier survival analysis comparing VVD-065 with vehicle ( n = 30 animals/group). Statistical significance was calculated by the Gehan–Breslow–Wilcoxon test (****, P < 0.0001). C, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic heterotopic model. Data are shown as mean ± SEM; n = 10 animals/group. Mice were dosed orally with VVD-065 at indicated doses. Statistical significance was calculated by two-way ANOVA (****, P ≤ 0.0001). OS, overall survival.
    Figure Legend Snippet: VVD-065 exhibits strong antitumor effects in syngeneic settings. A and B, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic orthotopic model. KLN-205 cells were injected into the tail vein of DBA/2 animals and then dosed with vehicle or VVD-065 50 mg/kg once a day (QD). A, Representative hematoxylin and eosin images of lungs from non-tumor bearing animals, vehicle-treated animals, and VVD-065–treated animals. B, Kaplan–Meier survival analysis comparing VVD-065 with vehicle ( n = 30 animals/group). Statistical significance was calculated by the Gehan–Breslow–Wilcoxon test (****, P < 0.0001). C, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic heterotopic model. Data are shown as mean ± SEM; n = 10 animals/group. Mice were dosed orally with VVD-065 at indicated doses. Statistical significance was calculated by two-way ANOVA (****, P ≤ 0.0001). OS, overall survival.

    Techniques Used: Injection



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    Image Search Results


    VVD-065 exhibits strong antitumor effects in syngeneic settings. A and B, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic orthotopic model. KLN-205 cells were injected into the tail vein of DBA/2 animals and then dosed with vehicle or VVD-065 50 mg/kg once a day (QD). A, Representative hematoxylin and eosin images of lungs from non-tumor bearing animals, vehicle-treated animals, and VVD-065–treated animals. B, Kaplan–Meier survival analysis comparing VVD-065 with vehicle ( n = 30 animals/group). Statistical significance was calculated by the Gehan–Breslow–Wilcoxon test (****, P < 0.0001). C, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic heterotopic model. Data are shown as mean ± SEM; n = 10 animals/group. Mice were dosed orally with VVD-065 at indicated doses. Statistical significance was calculated by two-way ANOVA (****, P ≤ 0.0001). OS, overall survival.

    Journal: Cancer Discovery

    Article Title: A Covalent Allosteric Molecular Glue Suppresses NRF2-Dependent Cancer Growth

    doi: 10.1158/2159-8290.CD-25-1187

    Figure Lengend Snippet: VVD-065 exhibits strong antitumor effects in syngeneic settings. A and B, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic orthotopic model. KLN-205 cells were injected into the tail vein of DBA/2 animals and then dosed with vehicle or VVD-065 50 mg/kg once a day (QD). A, Representative hematoxylin and eosin images of lungs from non-tumor bearing animals, vehicle-treated animals, and VVD-065–treated animals. B, Kaplan–Meier survival analysis comparing VVD-065 with vehicle ( n = 30 animals/group). Statistical significance was calculated by the Gehan–Breslow–Wilcoxon test (****, P < 0.0001). C, Antitumor efficacy of VVD-065 in the KLN-205 syngeneic heterotopic model. Data are shown as mean ± SEM; n = 10 animals/group. Mice were dosed orally with VVD-065 at indicated doses. Statistical significance was calculated by two-way ANOVA (****, P ≤ 0.0001). OS, overall survival.

    Article Snippet: KLN-205 cells were harvested in the exponential growth phase and suspended in 100 μL PBS to deliver 0.5 × 10 6 cells via a tail vein injection in DBA/2 mice (The Jackson Laboratory).

    Techniques: Injection